Course	BIO 114 Biology of Non-infectious Disease
Professor	John Ferguson
CRN	16276
Schedule	Tu Th 2:30 - 3:50 pm HEG 102 Th (Lab A) 9:00 - 12:00 pm ROSE 305 or Fr (Lab B) 9:30 - 12:30 pm ROSE 305
Distribution	OLD: E/G	NEW: Laboratory Science

While both morbidity and mortality from infectious disease declined steadily during the 20th century in developed nations, they remained constant for noninfectious diseases. Students examine the reasons for this failure to deal more effectively with these conditions as they study various specific diseases. Examples include inherited diseases such as sickle-cell anemia, Huntington's disease, and cystic fibrosis; endocrine disorders such as acromegaly; nutrional disorders such as vitamin and mineral deficiencies; therapeutic drug addiction and toxicities; various poisonings such as plant intoxications and rattlesnake envenomation; cardiovascular diesases such as myocardial infarctions and cerebrovascular accidents; neurological diseases such as Parkinson's disease and Alzheimer's disease; allergies; and autoimmune diseases such as myasthenia gravis, multiple sclerosis, and diabetes mellitus. Many of the readings are relatively nontechnical case histories, but the biology underlying each condition is thoroughly developed. This course is of interest to those focusing on a career in the health professions, but is also designed to provide liberal arts students with some degree of medical literacy in these health issues. The laboratory portion introduces students to human physiology as it relates to disease. Prerequisites: experience in high school biology and chemistry; Biology 141 and 142 or the equivalents strongly recommended. On-line

Course	BIO 144 Biostatistics
Professor	Robert Cutler
CRN	16277
Schedule	Mon Wed 9:50 - 11:50 am HDR 101A
Distribution	OLD: E/Q	NEW: Math and Computing

Cross-listed: Science, Technology & Society

This course provides a background in (1) the basic methods of data analysis for biologists, (2) applications of mathematics to the description of biological phenomena, and (3) the generation of testable hypotheses from models of biological processes. The goal of this course is to give students a general idea of what statistical methods are commonly used in biology, which methods are appropriate for which types of data, and to provide an in-depth examination of how the methods work. Among topics covered are elementary probability and statistics, fitting and hypothesis testing, characteristics of frequency distributions, regression analysis, and some multivariate based methods. Prerequisite: eligibility for Q courses. On-line

Course	BIO 151 From Genes to Traits
Professor	Michael Tibbetts
CRN	16278
Schedule	Mon Wed 9:00 - 10:20 am HEG 102 Mon (Lab A) 1:30 -4:30 pm ROSE 305 or Tu (Lab B) 1:30 -4:30 pm ROSE 305
Distribution	OLD: E/G/Q	NEW: Laboratory Science

Cross-listed: Science, Technology & Society

This course takes an introductory look at the relationships between genetics, environment, and biochemistry. It is intended for students with a strong interest in science and is appropriate for biology majors. The course will begin with an examination of heredity in both classical and modern molecular contexts. It will then focus on the relationships between genes and proteins, and the complex biochemical interactions that produce a phenotype. The course will culminate in a discussion of the ways in which the environment interacts with multiple genes to influence complex traits, for example schizophrenia, and the modern methods applied to the problem of identifying the genetic components of these traits. The laboratory will provide an opportunity to examine some of the principles discussed in the lecture in more detail and to become acquainted with some of the methodologies and instrumentation found in a modern biology laboratory. Prerequisite: eligibility for Q courses, and experience in high school biology and chemistry. On-line

Course	BIO 202 Evolution
Professor	Robert Cutler
CRN	16447
Schedule	Tu Th 2:20 -4:20 pm HEG 201
Distribution	OLD: E/G	NEW: Laboratory Science

Examines the following areas of evolution: population and quantitative genetics, natural and sexual selection, adaptation, speciation, and the major themes in phylogenetic evolution. Basic theory as well as empirical evidence for evolutionary processes that occur in both natural and computer-modeled populations are explored. Prerequisite: Biology 201 or permission of the instructor. On-line

Course	BIO 211 Metabolic Disease: From Genetics to Diet
Professor	Robert Cutler
CRN	16281
Schedule	Fr 1:30 -3:30 pm OLIN 307
Distribution	OLD: E/G	NEW: Laboratory Science

(2 credits) This course will examine human metabolism through instances in which it fails to function correctly. Some diseases with direct bearing on human metabolism include leptin deficiency, severe childhood epilepsy, hyper- and hypocholesterolemia, type I and II diabetes, hypogonadism, and more complex disease states such as Syndrome X and morbid obesity. Although some familial instances of these diseases do occur and have been attributed to the loss of single genes, others such as Syndrome X occur in up to 25% of the population and are most likely the result of multiply interacting factors. The environmental versus genetic components of these diseases as well as methods to regulate the metabolic system such as diet composition, exercise, and medication will also be discussed. During the semester we will visit several researchers at Rockefeller University who have been responsible for key insights into these processes. (Limited to 11 students)

Prerequisites: BIO 201 or permission of instructor. On-line

Course	BIO 302 Molecular Biology
Professor	Michael Tibbetts
CRN	16282
Schedule	Tu 9:50 - 11:50 am PRE 110 Th 9:00 - 12:00 pm PRE 110
Distribution	OLD: E/G	NEW: Laboratory Science

This course explores molecular aspects of gene expression in both prokaryotic and eukaryotic systems. Topics include DNA structure, replication, and repair; DNA transcription; RNA structure and processing; and polypeptide synthesis. The course also covers various mechanisms involved in the regulation of gene expression. Emphasis is placed on a review of the current literature and the experimental approaches used in modern molecular biological research. The laboratory provides practical experience in such current techniques used in molecular biology as molecular cloning, restriction enzyme mapping, DNA sequencing, and nucleic acid hybridization. Prerequisites: Biology 201, Chemistry 201‑202. On-line

Course	BIO 308 / 408 Seminar in Biological Research
Professor	Staff
CRN	16283 / 16284
Schedule	Tu 7:30 -9:30 pm ALBEE 102
Distribution	OLD: E	NEW: N/A

2 credits Juniors and seniors concentrating in biology are strongly urged to take this two-credit course. Each senior presents personal research in progress or significant material from the current literature. Each junior presents an interesting paper of personal choice from the literature. The purpose of the seminar is to enhance communication among seniors about their research and to encourage juniors to become familiar with both the biological literature and research undertaken in the program. Prerequisite: permission of the instructor.

Course	BIO 312 Biogeochemical Cycles
Professor	Catherine O'Reilly
CRN	16285
Schedule	Mon Wed 9:00 - 10:20 am HEG 106
Distribution	OLD: E	NEW: N/A

Our planet is basically a closed system, and cycles of certain elements dictate life-determining processes. The nitrogen, phosphorus, and carbon cycles are of particular interest in understanding patterns of life on earth. At different time scales, geological, biological, and chemical processes all play important roles mediating the availability of these nutrients. We will examine how interactions between biological processes (like primary productivity) and geological processes (like rock weathering) influence nutrient availability and long-term climate. With this understanding, we will investigate how various human activities such as agriculture and energy consumption are affecting these cycles and the implications for these impacts. Prerequisites: Chemistry 142 and two Biology courses, at least one at the 200 level. On-line